Mitchell K.P. Lai

This study shows that parental intermittent fasting induces intergenerational molecular changes in the brain, affecting sensory pathways and sex-dependent gene expression in offspring.

This study identifies tissue-specific and shared molecular adaptations to intermittent fasting in liver, brain, and muscle using proteomics and transcriptomics.

This study shows intermittent fasting changes chromatin accessibility and gene expression in brain and muscle tissues of mice, affecting metabolic and functional pathways.

The paper examines how cerebrovascular disease markers and plasma p-tau181 interact to affect brain connectivity, grey matter volume, and cognitive decline over time.

This study shows that intermittent fasting reduces neurovascular damage and oxidative stress in a mouse model of vascular dementia.

This study compares hippocampal gene expression in young and old mice under chronic hypoperfusion and aging, identifying shared molecular pathways linked to vascular dementia.

This study shows that AIM2 inflammasome activation contributes to brain injury and cognitive impairment in a mouse model of vascular dementia.

This study identifies a dichotomic hypo-connected resting and hyper-responsive active phenotype in a mouse model of early tauopathy, with implications for Alzheimer's disease.