Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics
Yong Tao, Zheng Hu, Shaoping Ling, Shiou-Hwie Yeh, Weiwei Zhai, Ke Chen, Chunyan Li, Yu Wang, Kaile Wang, Hurng-Yi Wang, Eric A. Hungate, Kenan Onel, Jiang Liu, Changqing Zeng, Richard R. Hudson, , Chung-I Wu
The study analyzes genetic diversity in multiple hepatocellular carcinomas, finding that low-frequency mutations pre-exist and contribute to drug resistance, presenting challenges and opportunities for cancer therapeutics.
bioRxiv · Aug 25, 2015 · PreprintCancer Biology