James E. Gern

The paper compares immune profiles and microbiomes of breast milk from mothers with different farm exposures to identify associations with immune development and atopic disease.

This study shows that rhinovirus does not directly activate neutrophils but instead induces epithelial release of factors that enhance neutrophil migration and apical debris that triggers ROS production.

ELRi isolates immune cells from small blood samples, revealing impaired T-cell migration to CCL21 in pediatric asthma.

This study identifies a monoclonal antibody that neutralizes HCoV-HKU1 by mimicking sialic acid binding to block receptor engagement.

This study compares nasal and oral microbiomes of infants and adults, finding age-related differences in diversity, composition, and functional capabilities.

This study identifies cell type-specific DNA methylation changes in airway epithelial cells linked to early-life RSV infection and their association with subsequent wheezing.

The paper uses single-cell RNA sequencing to study how wheeze and early-life RSV infection affect airway epithelial development in children.

The paper identifies high-value CpGs in the human methylome associated with allergic sensitization using a custom array and WGBS data from airway epithelial cells.

This study identifies a genetic variant associated with reduced lung function in urban children and shows its mediation by DNA methylation linked to smoking exposure.

The paper analyzes longitudinal DNA methylation data to show that race-associated patterns are present at birth and primarily genetic, with strong genetic and weak non-genetic contributions.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

The paper identifies three distinct immune development trajectories in childhood using unsupervised clustering, revealing a high-risk atopic cluster associated with allergic diseases.

The paper tracks the upper airway microbiome changes in preschool children and links them to asthma-associated persistent wheeze, showing that bacterial shifts precede viral infections and symptoms in sensitized children.