Anne I. Sperling

Computational Analysis of Fibroblast Subpopulation Dynamics as a Driver of Fibrotic Foci Formation

This paper develops a multiscale computational model to study how Thy-1 expression in fibroblast subpopulations influences fibrotic foci formation in IPF.

Single-cell multiomic profiling of lung immune cells identifies novel asthma risk genes and cell-type specific functions

The paper uses single-cell multi-omics data to identify asthma risk genes and their cell-type specific functions in lung immune cells.

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.

This study integrates functional genomics and statistical fine-mapping to identify causal variants, regulatory elements, and effector genes for adult-onset and childhood-onset asthma.

Dynamic responses of human lung innate and adaptive immune cells highlight the roles of genes at asthma risk loci

The paper examines gene expression in human lung immune cells after stimulation, finding that genes at asthma risk loci show differential expression and that B cells express HLA-DQA2 and HLA-DQB2, suggesting a novel antigen presentation pathway in asthma.

Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung Diseases

This study uses single-cell RNA sequencing to identify common and distinct immune aberrations in IPF and FHP, revealing shared monocyte features and disease-specific lymphocyte and receptor repertoires.

PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease

This study uses PhIP-Seq to identify novel autoantibodies in ILD patients, revealing a new molecular endotype associated with inflammation and fibrosis.

Asthma-associated variants induce IL33 differential expression through a novel regulatory region

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.