Intracellular targeting of a light-activated GPCR elicits spatially selective signalling
Chantel Mastos, Christina G. Gangemi, Alexandra‐Madelaine Tichy, Bonan Liu, Cameron J. Nowell, Andrew M. Ellisdon, Harald Janovjak, Michelle L. Halls
This study uses an optogenetic platform to activate a GPCR at different intracellular membranes, showing location-dependent transcriptional responses.
bioRxiv · Jan 30, 2026 · PreprintPharmacology & Toxicology