Harald Janovjak

This study uses an optogenetic platform to activate a GPCR at different intracellular membranes, showing location-dependent transcriptional responses.

The paper develops a barcode-free sequencing method for ORF libraries and applies it to analyze GPCR variants and generate a new fluorescent protein fusion library.

This paper describes a F420-dependent chemogenetic tool that induces and releases protein dimerization by exploiting a mycobacterial oxidoreductase.

This paper optimizes optogenetically functionalized GPCRs to achieve specific in vivo neuromodulatory signaling in Drosophila, showing rescue of endogenous receptor function.

This paper demonstrates structure-guided optimization of light-activated chimeric GPCRs to enhance their function and spectral tuning capabilities.

This paper demonstrates optogenetic delivery of trophic signals using light-activated receptors to suppress disease phenotypes in Parkinson's disease models.

This study shows that LTP induces astroglial withdrawal, increasing glutamate spillover and inter-synaptic communication.

This study uses optogenetics to show that phosphorylation of neuroligin-1 promotes excitatory synaptic differentiation and potentiation.

The paper develops a genetic engineering strategy and vector library to rapidly generate light-controlled protein-protein interactions by fusing target proteins to light-sensitive domains.