Alexandra‐Madelaine Tichy

This study uses an optogenetic platform to activate a GPCR at different intracellular membranes, showing location-dependent transcriptional responses.

This paper optimizes optogenetically functionalized GPCRs to achieve specific in vivo neuromodulatory signaling in Drosophila, showing rescue of endogenous receptor function.

This paper demonstrates structure-guided optimization of light-activated chimeric GPCRs to enhance their function and spectral tuning capabilities.

This paper demonstrates optogenetic delivery of trophic signals using light-activated receptors to suppress disease phenotypes in Parkinson's disease models.

The paper develops a genetic engineering strategy and vector library to rapidly generate light-controlled protein-protein interactions by fusing target proteins to light-sensitive domains.