MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss
Shuke Xiao, Alan Sheng-Hwa Tung, Jan Spaas, Sipei Fu, Xudong Chen, Tuan Kiet Trinh, María Dolores Moya-Garzón, Veronica L. Li, Hannah T. Cessna, Kentaro Ito, Saranya C. Reghupathy, Chao Lin, Xuchao Lyu, Steffen Henning Raun, Miles D.W. Tyner, , Jonathan Z. Long
This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.
bioRxiv · Sep 28, 2026 · PreprintPhysiology