This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.

bioRxiv · Sep 28, 2026 · PreprintPhysiology

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

María Dolores Moya-Garzón, Mengjie Wang, Veronica L. Li, Xuchao Lyu, Wei Wei, Alan Sheng-Hwa Tung, Steffen Henning Raun, Meng Zhao, Laëtitia Voilquin, Hashim Islam, Bárbara Oliveira, Yuqin Dai, Jan Spaas, Antonio Delgado‐González, Kenyi Donoso, , Jonathan Z. Long

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

Cell · Nov 12, 2024Peer-reviewedBiochemistry

SLC17 transporters mediate renal excretion of Lac-Phe in mice and humans

Veronica L. Li, Shuke Xiao, Pascal Schlosser, Nora Scherer, Amanda L. Wiggenhorn, Jan Spaas, Alan Sheng-Hwa Tung, Edward D. Karoly, Anna Köttgen, Jonathan Z. Long

This study identifies SLC17A1 and SLC17A3 as key transporters for Lac-Phe excretion in urine, showing genetic and functional associations in mice and humans.

Nature Communications · Aug 12, 2024Peer-reviewedBiochemistry

Organism-wide secretome mapping uncovers pathways of tissue crosstalk in exercise

Wei Wei, Nicholas McIlvain Riley, Xuchao Lyu, Xiaotao Shen, Jing Guo, Meng Zhao, María Dolores Moya-Garzón, Himanish Basu, Alan Sheng-Hwa Tung, Veronica L. Li, Wentao Huang, Katrin J. Svensson, Michael P. Snyder, Carolyn Ruth Bertozzi, Jonathan Z. Long

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.

bioRxiv · Nov 21, 2022 · PreprintSystems Biology