A bottom-up approach to understanding ultrasound mediated blood-brain barrier opening using long and short pulses
Yuanyuan Shen, Yicong Cai, Chaofeng Qiao, Zhihui Liu, Yiluo Xu, Mengni Hu, Ji Zhang, Lin Ma, Fenfang Li
This study compares long and short pulse ultrasound effects on BBB opening, finding long pulses increase drug delivery but cause damage, while short pulses are safer and more uniform.
bioRxiv · Jun 11, 2025 · PreprintBiophysics