Author

Zhuoyan Liu

Shihezi University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Shengwen YangiD· 2 shared You Xu· 2 shared Zhenming LiuiD· 2 shared Bin DaiiD· 1 shared Chaofeng Qiao· 1 shared Fenfang LiiD· 1 shared Hao JiangiD· 1 shared Jiaxin HuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Shengwen YangORCID

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Author profile →

3 papers

Recent·Most cited

Tractable and Thermodynamically Consistent pKa Prediction via First-Dissociation Aggregation

Zhuoyan Liu, Qiuyin Zhu, Qingkun Li, Yuanxi Zhu, You Xu, Bin Dai, Yongsheng Li, Zhenming Liu, Shengwen Yang

This paper introduces DTi-pKa, a graph neural network that predicts pKa values with thermodynamic consistency and achieves high accuracy on benchmark datasets.

bioRxiv · Oct 6, 2026 · PreprintBioinformatics

Pair-complete structural gating enables Pareto optimization of de novo cyclic peptides with preserved binding geometry and improved developability

Yuanchao Hou, Yixin Zhang, Zhuoyan Liu, 彭新发, Ziye Liu, Miyesier Yusupujiang, You Xu, Jiaxin Hu, Zhenming Liu, Shengwen Yang

This paper introduces RF-PepTune, a method that improves cyclic peptide design by preserving binding geometry while optimizing multiple properties, achieving higher success rates in structural and functional criteria.

bioRxiv · Sep 29, 2026 · PreprintBioinformatics

Ultrasonic Modulation of Astrocytic and Neuronal Calcium Dynamics in Mouse Cortex

Yu Yong, Hao Jiang, Chaofeng Qiao, Zhuoyan Liu, Xiaohan Zhou, Yufeng Zhou, Fenfang Li

This study investigates how low-frequency focused ultrasound affects astrocyte and neuronal calcium dynamics in mouse cortex, finding state-dependent effects with greater astrocytic response in awake mice.

bioRxiv · Mar 3, 2025 · PreprintBioengineering