Inhibition of Endothelial Lipase by MEDI5884 Normalizes Phosphatidylinositol Levels in Coronary Artery Disease Patients
Anton I. Rosenbaum, Yue Huang, Ruipeng Mu, Kristina S. Kovacina, ChaoYu Jin, B. Timothy Hummer, Meina Liang, Joseph S. Grimsby
This study shows that MEDI5884 increases phosphatidylinositol levels in CAD patients by inhibiting endothelial lipase, correlating with improved HDL function and reverse cholesterol transport.
bioRxiv · May 30, 2024 · PreprintPharmacology & Toxicology