3D-printing-assisted, microfabricated devices reveal hierarchical and temporal mechanosensing in high-density fibroblast culture
Ghiska Ramahdita, Xiangjun Peng, Mohammad Jafari, Charlene Pobee, Riya Bhakta, Z Zhang, Austin C. Kellogg, Hsin-Yi Cindy Chou, Missy Pear, Fei Wang, David R. Schuftan, Yuan Hong, Michael A. David, Spencer P. Lake, Elliot L. Elson, , Nathaniel Huebsch
This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.
ACS Nano · May 8, 2026Peer-reviewedBioengineering