Chao Zhou

Differential Survival of Retinal Ganglion Cell Types Following Branch Retinal Vein Occlusion

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

Drosophila melanogaster Nepl15 gene deletion promotes anti-aging and anti-obesity phenotypes in a sex-dependent manner

This study shows that deleting the Nepl15 gene in Drosophila improves anti-aging and anti-obesity traits, with stronger effects in females than males.

3D-printing-assisted, microfabricated devices reveal hierarchical and temporal mechanosensing in high-density fibroblast culture

This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.

Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

This study establishes a Drosophila model of RVCL-S that recapitulates disease features, showing vascular deterioration and reduced lifespan in TREX1 mutant flies.

Application of Spectral Domain Optical Coherence Tomography To Guide Cochlear Implant Electrode Array

This paper demonstrates a custom SD-OCT system for real-time guidance of cochlear implant electrode arrays in mice and cadaveric human temporal bones.

Label free, capillary-scale blood flow mapping in vivo reveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature

This study uses an in vivo optical approach to show that low intensity focused ultrasound causes persistent microvascular dilation without microbubbles, suggesting vascular mechanisms may contribute to long-term neuromodulatory effects.

Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions

This paper introduces hHMA, a human heart-macrophage assembloid model that integrates autologous cardiac macrophages with heart organoids to study immune-cardiac interactions and disease mechanisms.