Guy M. Genin

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

This study identifies three sequential stages of actomyosin remodeling in podocyte injury across multiple kidney diseases, suggesting a structured, potentially reversible response.

This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.

The paper shows synaptopodin enables cells to adapt their adhesion structures to resist perpendicular forces by reorganizing the actin cytoskeleton and integrin-based adhesions.

The paper identifies a mechanical homeostasis mechanism in podocytes where balance between fluid shear stress and cellular contractility prevents injury, showing that reducing blood pressure can worsen outcomes when contractility is impaired.

The paper models how critical cell spacing drives a phase transition in matrix-mediated tissue condensation through mechanical feedback.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This study shows that mechanical stretching can disrupt pathological crosslinks in fibrotic tissues, reversing fibrosis in mice when combined with pharmacological treatment.

This study compares the musculoskeletal anatomy of bats and mice to understand adaptations enabling sustained overhead motion without injury.

This paper identifies tension anisotropy as the driver of implant-induced fibrosis and shows adhesive interfaces prevent it by distributing forces isotropically.

This study identifies mechanisms to improve mechanical stiffness in cellulose nanocrystal-reinforced soy protein isolate composites through surface modification and interfacial interactions.

This study uses atomic force microscopy to analyze phase separation on ruptured GUVs, revealing a stabilization mechanism for lipid domains.