Xiangjun Peng

This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.

The paper shows synaptopodin enables cells to adapt their adhesion structures to resist perpendicular forces by reorganizing the actin cytoskeleton and integrin-based adhesions.

The paper models how critical cell spacing drives a phase transition in matrix-mediated tissue condensation through mechanical feedback.

This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.

This study shows that mechanical stretching can disrupt pathological crosslinks in fibrotic tissues, reversing fibrosis in mice when combined with pharmacological treatment.