Reduced Gene Dosage of Histone H4 Prevents CENP-A Mislocalization in Saccharomyces cerevisiae
Jessica R. Eisenstatt, Kentaro Ohkuni, Wei-Chun Au, Olivia Preston, Evelyn Suva, Michael Costanzo, Charles Boone, Munira A. Basrai
This study identifies genes that contribute to mislocalization of overexpressed Cse4 and shows reduced H4 dosage facilitates Cse4 sumoylation and mislocalization, leading to synthetic dosage lethality.
bioRxiv · May 29, 2020 · PreprintGenetics