Munira A. Basrai

This paper identifies Yra2's role in ubiquitin-mediated proteolysis of Cse4 to prevent its mislocalization and maintain chromosomal stability in budding yeast.

This study shows Scm3 interacts with N-terminal Cse4 to stabilize kinetochore assembly in budding yeast and suggests implications for human disease.

This study identifies Matrin3's role in regulating CDC14B alternative splicing, which affects cell proliferation and mitotic spindle dynamics in colorectal cancer cells.

The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.

This study identifies genes that contribute to mislocalization of overexpressed Cse4 and shows reduced H4 dosage facilitates Cse4 sumoylation and mislocalization, leading to synthetic dosage lethality.

This study identifies K65 as a SUMO site on Cse4 and shows that sumoylation regulates its ubiquitin-mediated proteolysis to prevent mislocalization and maintain genome stability.

This study shows that CAPE inhibits growth of bub1Δ yeast strains with high chromosomal instability by suppressing chromosome mis-segregation.