Author

Wei-Chun Au

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Kentaro Ohkuni· 2 shared Munira A. BasraiiD· 2 shared Charles Boone· 1 shared Evelyn Suva· 1 shared Jack Warren· 1 shared Jessica R. Eisenstatt· 1 shared Michael CostanzoiD· 1 shared Olivia Preston· 1 shared

Activity by Year

2018-2020 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Kentaro Ohkuni

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2 papers

Recent·Most cited

Reduced Gene Dosage of Histone H4 Prevents CENP-A Mislocalization in Saccharomyces cerevisiae

Jessica R. Eisenstatt, Kentaro Ohkuni, Wei-Chun Au, Olivia Preston, Evelyn Suva, Michael Costanzo, Charles Boone, Munira A. Basrai

This study identifies genes that contribute to mislocalization of overexpressed Cse4 and shows reduced H4 dosage facilitates Cse4 sumoylation and mislocalization, leading to synthetic dosage lethality.

bioRxiv · May 29, 2020 · PreprintGenetics

N-terminal sumoylation of centromeric histone H3 variant Cse4 regulates its proteolysis to prevent mislocalization to non-centromeric chromatin

Kentaro Ohkuni, Reuben Levy-Myers, Jack Warren, Wei-Chun Au, Yoshimitsu Takahashi, Richard E. Baker, Munira A. Basrai

This study identifies K65 as a SUMO site on Cse4 and shows that sumoylation regulates its ubiquitin-mediated proteolysis to prevent mislocalization and maintain genome stability.

G3 Genes Genomes Genetics · Feb 8, 2018Peer-reviewedMolecular Biology