Simon J. Dovedi

This paper develops a low-matrix co-culture platform to evaluate T cell engager activity in patient-derived CRC organoids, showing dose-dependent cytotoxicity and immune activation across diverse models.

This study shows PD-1 blockade enhances T cell activation by altering ligand interactions between CD28, CTLA4, and PD-1, leading to stronger CD28-CD80 co-stimulation.

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.