Neuroinflammation induces nerve growth factor dependent nociceptor sensitisation in a neonatal rodent model of platinum-based chemotherapy induced neuropathic pain
Marlene E. Da Vitoria Lobo, Lydia D. Hardowar, Tameille Valentine, Lucy Tomblin, Charlotte Guest, Dhyana Sharma, Benjamin Dickins, Mark J. Paul‐Clark, Richard P. Hulse
This study shows cisplatin induces NGF-mediated neuroinflammation and nociceptor sensitisation in a neonatal rodent model of chemotherapy-induced neuropathic pain, identifying NGF/TrkA as a potential therapeutic target.
Disease Models & Mechanisms · Oct 21, 2024Peer-reviewedNeuroscience