Richard P. Hulse

This study shows that AT1 receptor activation in dorsal horn pericytes causes vasoconstriction and pain hypersensitivity, which can be prevented by losartan.

This study shows that connexin 43-mediated mitochondrial transfer from monocytes to damaged sensory neurons prevents cisplatin-induced neurodegeneration.

This study shows cisplatin induces NGF-mediated neuroinflammation and nociceptor sensitisation in a neonatal rodent model of chemotherapy-induced neuropathic pain, identifying NGF/TrkA as a potential therapeutic target.

The paper uses intravital imaging in mice to study spinal cord vascular permeability and function in real time.

The paper shows that hypoxia in the spinal dorsal horn, caused by vascular issues, activates sensory neurons and leads to neuropathic pain, which can be reversed by inhibiting carbonic anhydrase.