HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransduction
Katrin Schrenk-Siemens, Jörg Pohle, Charlotte Rostock, Muad Y Abd El Hay, Ruby M. Lam, Marcin Szczot, Shiying Lu, Alexander Theodore Chesler, Jan Siemens
The paper generates hESC-derived nociceptor-like cells and shows they exhibit mechano-nociceptive characteristics requiring PIEZO2 for mechanotransduction.
bioRxiv · Aug 23, 2019 · PreprintNeuroscience