Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain
Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Hagen Wende, Katrin Schrenk-Siemens, Anna A DePaoli-Roach, Anna M. Hagenston, Anke Tappe‐Theodor, Manuela Simonetti, Rohini Kuner, Thomas Henry Fleming, Jan Siemens
This study shows that spinal astrocytic glycogen dynamics, regulated by PTG, are critical for maintaining persistent pain through neuronal plasticity and metabolic coupling with neurons.
bioRxiv · Dec 3, 2022 · PreprintNeuroscience