Modeling lung adenocarcinoma using layer-by-layer nanoparticles mitigates innate immune cell activation
Vidit Bhandarkar, Elen Torres-Mejia, Taylor A. Heim, Namita Nabar, Tamara G. Dacoba, Zachary J. Rogers, Nicolas Mathey‐Andrews, Sean-Luc Shanahan, Chau Vo, Adam G. Berger, John Christopher Love, Tyler Jacks, Paula Therese Hammond, Stefani Spranger
This paper develops a nanoparticle-based method to deliver Cre mRNA for lung adenocarcinoma modeling in mice, avoiding immune activation and enabling accurate tumor-immune dynamics studies.
bioRxiv · Sep 20, 2026 · PreprintImmunology