Paula Therese Hammond

Modeling lung adenocarcinoma using layer-by-layer nanoparticles mitigates innate immune cell activation

This paper develops a nanoparticle-based method to deliver Cre mRNA for lung adenocarcinoma modeling in mice, avoiding immune activation and enabling accurate tumor-immune dynamics studies.

Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation

This study shows that the outer polyion layer of layer-by-layer nanoparticles affects protein corona formation, which influences their biodistribution and therapeutic efficacy.

Polyamines buffer labile iron to suppress ferroptosis

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

This paper develops a nanoparticle platform to target TLR3 agonist to antigen-presenting cells, improving cancer immunotherapy safety and efficacy by reducing systemic toxicity and enhancing tumor targeting.

A Multivalent Peptide-Polymer Conjugate Material Mimics STING to Therapeutically Activate Innate Immune Signaling

This paper develops a multivalent peptide-polymer conjugate that mimics STING to activate innate immune signaling and shows tumor regression in ovarian cancer models.

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Surface avidity of anionic polypeptide coatings target nanoparticles to cancer-associated amino acid transporters

The paper shows that anionic polypeptide coatings on nanoparticles bind to cancer-associated amino acid transporters, enabling targeted drug delivery through electrostatic interactions and transporter clustering.

'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.

Investigating Bio-Nano Interactions of PEGylated Cationic Polyamidoamine (PAMAM) Dendrimers within Synovial Joints

This study investigates how PEGylated cationic PAMAM dendrimers interact with proteins in synovial fluid and how these interactions affect their uptake in cartilage and internalization by chondrocytes.

A Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting

This paper develops a modular LbL NP platform for targeting HSPCs and demonstrates its efficacy in both murine and human cells.

Pooled nanoparticle screening using a chemical barcoding approach

This paper develops a chemical barcoding platform using halocodes to enable high-sensitivity detection and pooled screening of nanoparticles, demonstrating its utility in quantifying delivery and spatial mapping.