Sean-Luc Shanahan

This paper develops a nanoparticle-based method to deliver Cre mRNA for lung adenocarcinoma modeling in mice, avoiding immune activation and enabling accurate tumor-immune dynamics studies.

The paper uses single-molecule imaging and spatial transcriptomics to show a spatially graded threat-sensing strategy in lung tissue during influenza infection, with higher PRR expression in inner stroma leading to more potent immune responses.

This study shows that LC3B phosphorylation by STK4 regulates FYCO1 binding and directional transport of autophagosomes, switching their movement from retrograde to anterograde under starvation conditions.