Adaptive sampling-based enrichment enables genome reconstruction of intracellular symbionts despite host background and reference divergence
Wei-Kang Huang, Cheng-Hao Yang, Hui Chung, Yen-Chen Lee, YL Wu, Yen-Tong Chen, Mei-Hsiu Wan, Wen-Sheng Yeh, Yu-Ping Hong, Tsung-Hua Wu, Jian‐Chiuan Li, Wei‐Liang Liu, Chun‐Hong Chen, Ying-Tsong Chen
This paper demonstrates that adaptive sampling-based sequencing enables efficient genome reconstruction of intracellular symbionts from host-dominated samples, achieving high completeness and revealing structural divergence from reference genomes.
bioRxiv · Mar 27, 2026 · PreprintGenomics