Adaptive sampling-based enrichment enables genome reconstruction of intracellular symbionts despite host background and reference divergence
Wei-Kang Huang, Cheng-Hao Yang, Hui Chung…·Ying-Tsong Chen
This paper demonstrates that adaptive sampling-based sequencing enables efficient genome reconstruction of intracellular symbionts from host-dominated samples, achieving high completeness and revealing structural divergence from reference genomes.