Acquired resistance to sotorasib in mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1, a regulator of cap-dependent translation
Ismail Mustafa Meraz, Shuhong Wu, Yi Xu, Lihui Gao, Meng Feng, Chenghui Ren, Renduo Song, Ran Zhang, Qi Wang, Yuanxin Xi, Sung Yun Jung, Jing Wang, Bingliang Fang, Mourad Majidi, Jack A. Roth
This study identifies PI3K-mTOR pathway inhibition as a strategy to overcome acquired resistance to KRASG12C inhibitors in NSCLC by targeting 4E-BP1.
bioRxiv · Mar 18, 2025 · PreprintCancer Biology