The cation channel mechanisms of subthreshold inward depolarizing currents in the VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior
Jing Wang, Min Su, Dongmei Zhang, Ludi Zhang, Chenxu Niu, Chaoyi Li, Shuangzhu You, Yuqi Sang, Yongxue Zhang, Xiaona Du, Hailin Zhang
This study identifies NALCN and TRPC6 cation channels as mediators of subthreshold inward depolarizing currents in VTA DA neurons and links their down-regulation to depression-like behavior in chronic stress.
eLife · Dec 6, 2024Peer-reviewedNeuroscience