Panax notoginseng saponins protect the blood brain barrier against oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling axis
Lili Fan, Shukun Qu, Chenxue Miao, Dongjie Wu, Yuan Rao, Weisong Xu, Yanping He, Rui Ding, Guang Song
This study shows that Panax notoginseng saponins protect the blood-brain barrier from oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling pathway and modulating tight junction proteins.
International Journal of Biological Macromolecules · Feb 26, 2026Peer-reviewedPharmacology & Toxicology