Acquired Amphotericin B Resistance Attributed to a Mutated ERG3 in Candidozyma auris
Lauryn Massic, Laura A. Doorley, Sarah J Jones, Irene Richardson, Danielle Denise Siao, Lauren Siao, Philip Dykema, Chi N. Hua, Emily Schneider, Christina A. Cuomo, Phillip David Rogers, Stephanie Van Hooser, Josie E. Parker, Steven L. Kelly, David C. Hess, , Mark Pandori
This paper describes a clinical case of acquired amphotericin B resistance in Candidozyma auris due to a frameshift mutation in ERG3, showing a fitness cost associated with altered sterol production.
Antimicrobial Agents and Chemotherapy · Sep 22, 2025Peer-reviewedGenetics