Josie E Parker

This study identifies CYP123 as a key enzyme in mycobacterial lanosterol catabolism, showing it works with CYP51 to oxidize C14-demethylated sterols, expanding the known sterol utilization beyond cholesterol.

This paper describes a clinical case of acquired amphotericin B resistance in Candidozyma auris due to a frameshift mutation in ERG3, showing a fitness cost associated with altered sterol production.