Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects
Li Li, Jong Bin Choi, Chi-Hong Shin, Saw Htun, Sherry Mestan, Anna J. Voss, Jennifer L. Shadrach, Alyssa Puno, Dhriti Nagar, Nephy Ramirez, Daniela Rojo, Samuel H. Lee, Erin M. Gibson, Julia A. Kaltschmidt, Steven A. Sloan, , Anca M. Pașca
This study shows hypoxia disrupts astrocytic circadian rhythms, reducing synaptosome phagocytosis and linking this to ASD-related synapse defects.
bioRxiv · Feb 22, 2024 · PreprintNeuroscience