Dhriti Nagar

Adrenomedullin Restores Mitochondrial Bioenergetics and Rescues Interneuron Phenotypes in Human Models of 22q11.2 Deletion Syndrome

This study identifies mitochondrial dysfunction in 22q11.2DS interneurons and shows that Adrenomedullin rescues these defects through distinct signaling pathways.

Adrenomedullin restores human cortical interneurons migration defects induced by hypoxia

The paper shows hypoxia impairs human cortical interneuron migration and demonstrates adrenomedullin can restore this defect through the cAMP/PKA pathway.

Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects

This study shows hypoxia disrupts astrocytic circadian rhythms, reducing synaptosome phagocytosis and linking this to ASD-related synapse defects.

Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching

This study identifies Fmn2 and ADF as regulators of axonal F-actin patch dynamics, showing Fmn2 stabilizes these patches while ADF promotes their disassembly, influencing collateral branching.

Development of motor neurons and motor activity in zebrafish requires F-actin nucleation by Fmn2b

This study shows that Fmn2b is essential for motor neuron development and function in zebrafish, with loss-of-function leading to motor deficits and impaired axon branching.

The formin Fmn2 is required for the development of an excitatory interneuron module in the zebrafish acoustic startle circuit

This study identifies Fmn2's role in zebrafish neural circuit development, specifically in the formation of spiral fiber neurons critical for the acoustic startle response.