Julia A. Kaltschmidt

Loss of Sall3 eliminates presynaptic inhibition of sensory motor circuits and impairs adaptive motor behavior

This study shows that Sall3 is essential for forming GABApre synapses on Ia afferents, and its loss disrupts motor behavior by impairing presynaptic inhibition.

Transmembrane aminopeptidase Q (Taqpep) is a common mechanism in the establishment of periodic patterning in skin and intestine

This study identifies Taqpep as a conserved mediator of periodic patterning in mammalian tissues, showing its role in both skin and intestinal development through mutant mouse models.

Abnormal enteric nervous system organization and gastrointestinal motility in mice with valproic acid-induced neural tube defects

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.

This study identifies Gpr37 as a gene expressed in enteric glia cells of the myenteric plexus and shows its role in LPS-induced reactive gliosis and GI dysmotility.

Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

Enteric glutamatergic interneurons regulate intestinal motility

This study identifies glutamatergic neurons as key regulators of intestinal motility by showing their synaptic connections and functional roles in gut transit.

Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons

The paper introduces GAT, a tool for automated analysis of enteric neurons in gut tissue images, improving accuracy and throughput over manual methods.

Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects

This study shows hypoxia disrupts astrocytic circadian rhythms, reducing synaptosome phagocytosis and linking this to ASD-related synapse defects.

Loss of ASD-Related Molecule Cntnap2 Affects Colonic Motility in Mice

This study investigates the role of Cntnap2 in GI motility using Cntnap2 mutant mice, finding altered colonic motility without affecting ENS organization.

Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus

This study compares three wholemount dissection methods for neuronal subtype markers in the mouse myenteric plexus, finding that one method reduces marker labeling.

Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

The paper identifies spontaneous neurogenic GI motility in ex vivo assays and links it to cholinergic signaling in enteric nervous system development.

Single-Cell Multiome Sequencing Clarifies Enteric Glial Cell Diversity and Identifies an Intraganglionic Population Poised for Neurogenesis

The paper uses single-cell multiome sequencing to study enteric glial cells (EGCs) and identifies a subset with neurogenic potential.

Regional cytoarchitecture of the adult and developing mouse enteric nervous system

The paper demonstrates that the enteric nervous system is organized into circumferential stripes with regionally distinct development and neuronal composition.

Anatomical and functional maturation of the mid-gestation human intestine

This study examines anatomical and functional maturation of the human fetal intestine, identifying when the enteric nervous system becomes functionally active.

hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function

This study develops hPSC-derived enteric ganglioids to model human ENS development and function, identifying drug candidates and PDGFR inhibition as key factors in NO neuron specification.

Landscape of human spinal cord cell type diversity at midgestation

The paper profiles midgestation human spinal cord cells at single-cell resolution, revealing early diversification of motor neurons and glial cell types.

COUNTEN an AI-driven tool for rapid, and objective structural analyses of the Enteric Nervous System

COUNTEN is an AI tool that rapidly and objectively enumerates and classifies enteric neurons in murine ileal plexus tissue, improving upon manual methods by reducing time and bias.

Single-cell transcriptomic analysis of the adult mouse spinal cord

This study profiles single-nucleus transcriptomes of adult mouse spinal motor neurons to identify transcriptional subtypes and their functional roles.