Anca M. Pașca

This study identifies mitochondrial dysfunction in 22q11.2DS interneurons and shows that Adrenomedullin rescues these defects through distinct signaling pathways.

The paper shows hypoxia impairs human cortical interneuron migration and demonstrates adrenomedullin can restore this defect through the cAMP/PKA pathway.

This study identifies FAM53C as a regulator of the G1/S cell cycle transition, showing it interacts with DYRK1A and affects cell cycle progression in cultured cells and organoids.

The paper presents a single cell multiomic atlas of human lung development, identifying regulatory elements and gene programs, and linking genetic variants to pulmonary function.

The paper presents a single-cell multi-omics atlas of human development and uses deep learning to analyze regulatory DNA motifs and their impact on chromatin accessibility and gene expression.

The paper identifies CXCL12 as a genetic driver of coronary artery anatomy variation through GWAS and mouse models, showing its role in fetal coronary development.

This study shows hypoxia disrupts astrocytic circadian rhythms, reducing synaptosome phagocytosis and linking this to ASD-related synapse defects.

This study uses human assembloids to investigate how CACNA1G gene variants affect thalamocortical pathway function in neuropsychiatric disorders.

This study examines anatomical and functional maturation of the human fetal intestine, identifying when the enteric nervous system becomes functionally active.

This study investigates interneuron migration defects in Timothy syndrome using human forebrain assembloids and identifies pharmacological targets to rescue migration abnormalities.

The paper profiles midgestation human spinal cord cells at single-cell resolution, revealing early diversification of motor neurons and glial cell types.

The paper maps gene-regulatory dynamics in the developing human cerebral cortex using single-cell data, identifying key transcription factors and disrupted regulatory elements in ASD.