Augmenting Radiation Sensitivity by Targeting PAR-Dependent Replication Fork Vulnerability in IDH-Mutant Glioma
Yosuke Kitagawa, Ali M. Nasser, Ami Kobayashi, Ethan Wetzel, Lisa Melamed, Chia-Chen Chang, Hiroaki Nagashima, Julie J. Miller, Hiroaki Wakimoto, Daniel P. Cahill
This study shows that inhibiting PARG enhances radiosensitivity in IDH1-mutant glioma cells by disrupting PAR-dependent replication fork processes and S-phase kinetics.
bioRxiv · Aug 10, 2026 · PreprintCancer Biology