Author

Hiroaki Wakimoto

Harvard UniversityORCID 0000-0001-8225-241XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel P. CahilliD· 2 shared Alexander C.-Y. Tsai· 1 shared Ali M. NasseriD· 1 shared Ami KobayashiiD· 1 shared Chia-Chen Chang· 1 shared Christian GegeiD· 1 shared Daniel VittiD· 1 shared Diana D. ShiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Daniel P. CahillORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 10, 2026

Augmenting Radiation Sensitivity by Targeting PAR-Dependent Replication Fork Vulnerability in IDH-Mutant Glioma

Yosuke Kitagawa, Ali M. Nasser, Ami Kobayashi…·Daniel P. Cahill

This study shows that inhibiting PARG enhances radiosensitivity in IDH1-mutant glioma cells by disrupting PAR-dependent replication fork processes and S-phase kinetics.

DOI 10.64898/2026.08.08.743634

humanexperimental assay

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Cancer BiologybioRxivPreprintApr 17, 2026

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity

Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba…·Diana D. Shi

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

DOI 10.64898/2026.04.14.715350

humanproteomics

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