Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19
Abdul Rouf Banday, Megan Lynn Stanifer, Oscar Flórez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad Atif Zahoor, Lisa J. Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Gregory S. Barsh, Leslie G. Biesecker, David L. Boyle, , Ludmila Prokunina‐Olsson
The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.
Nature Genetics · Jul 14, 2022Peer-reviewedGenetic & Genomic Medicine