Chromatin condensates tune nuclear mechano-sensing in Kabuki Syndrome by constraining cGAS activation
Sarah D’Annunzio, Martina Di Santo, Giulia Vitali, Lucia Santomaso, Daniela Michelatti, Leonardo Morelli, Chiara Bernardis, Maulana Ariefai, Shiza Nasir, Sara Lago, Lorenzo Lunelli, Claudia Testi, Emanuele Pontecorvo, Alessandro Poli, Fabrizio A. Pennacchio, , Alessio Zippo
The paper shows that chromatin condensates, regulated by MLL4, modulate nuclear mechano-sensing and prevent cGAS-STING activation in Kabuki Syndrome.
The EMBO Journal · Aug 12, 2026Peer-reviewedMolecular Biology