Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca2+ activity in chemotherapy-induced peripheral neuropathy
John L. Shannonhouse, Matteo Bernabucci, Rubén Sánchez Gómez, Hyeonwi Son, Yan Zhang, Chih-Hsuan Ai, Hirotake Ishida, Yu Shin Kim
This study tests mGluR agonists and meclizine as treatments for CIPN, finding they reduce pain and DRG neuron Ca2+ activity in a mouse model.
Journal of Neuroscience · Jun 30, 2022Peer-reviewedNeuroscience