John L. Shannonhouse

This study shows that vagus nerve stimulation reduces TMD-related pain by activating dopaminergic vagal afferents that modulate trigeminal nociceptors.

This study uses in vivo GCaMP3 Ca2+ imaging to analyze neuronal activity in trigeminal ganglia of TMJ injury models, finding increased responsiveness to stimuli and the effectiveness of CGRP antagonists in reducing hypersensitivity.

This study investigates how forced mouth opening induces hyperalgesia and peripheral sensitization in mice following temporomandibular joint injury.

This study tests mGluR agonists and meclizine as treatments for CIPN, finding they reduce pain and DRG neuron Ca2+ activity in a mouse model.

This study shows capsaicin pretreatment reduces postoperative pain by decreasing Ca2+ activity in primary sensory neurons and degenerating nerve fibers in the skin.

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.