Yu Shin Kim

Vagal dopaminergic afferents link interoception to trigeminal pain modulation

This study shows that vagus nerve stimulation reduces TMD-related pain by activating dopaminergic vagal afferents that modulate trigeminal nociceptors.

Multiscale 3D whole joint cellular and molecular mapping dissects the relationship between structure and pain

This paper introduces a method for 3D multiscale analysis of joints, revealing neurovascular changes linked to pain and degeneration across species and tissues.

Elucidation of neuronal activity in mouse models of TMJ injury by in vivo GCaMP Ca2+ imaging of intact trigeminal ganglion neurons

This study uses in vivo GCaMP3 Ca2+ imaging to analyze neuronal activity in trigeminal ganglia of TMJ injury models, finding increased responsiveness to stimuli and the effectiveness of CGRP antagonists in reducing hypersensitivity.

Forced mouth opening induces post-traumatic hyperalgesia and associated peripheral sensitization after temporomandibular joints injury in mice

This study investigates how forced mouth opening induces hyperalgesia and peripheral sensitization in mice following temporomandibular joint injury.

Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca2+ activity in chemotherapy-induced peripheral neuropathy

This study tests mGluR agonists and meclizine as treatments for CIPN, finding they reduce pain and DRG neuron Ca2+ activity in a mouse model.

Imaging sensory transmission and neuronal plasticity in primary sensory neurons with genetically-encoded voltage indicator, ASAP4.4-Kv

This paper uses a novel genetically-encoded voltage indicator to study voltage dynamics in primary sensory neurons during various stimuli and injury, revealing synchronization and coding changes.

Capsaicin pretreatment alleviates postoperative pain and reduces primary sensory neuron Ca2+ activity

This study shows capsaicin pretreatment reduces postoperative pain by decreasing Ca2+ activity in primary sensory neurons and degenerating nerve fibers in the skin.

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.

In vivo calcium imaging visualizes peripheral neuron sensitization in murine osteoarthritis

This study uses in vivo calcium imaging to show that DMM surgery increases the number of sensory neurons responding to mechanical stimuli in mice, indicating neuronal sensitization.