Lytic IFNγ is stored in granzyme B-containing cytotoxic granules and co-secreted by effector CD8⁺ T cells
Xuemei Li, Claudia Schirra, Marie-Louise Wirkner, Szu-Min Tu, Chin-Hsin Lin, Meltem Hohmann, Nadia Alawar, Abed Alrahman Chouaib, Ute Becherer, Varsha Pattu, Jens Rettig, Elmar Krause, Hsin‐Fang Chang
The paper identifies lytic IFNγ stored in granzyme B-containing cytotoxic granules and co-secreted with GzmB by effector CD8⁺ T cells during immunological synapse formation.
bioRxiv · Jan 29, 2025 · PreprintImmunology