Hsin‐Fang Chang

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

This study creates synthetic lymphatic tissues that integrate with human immune cells to expand therapeutic T cells.

The paper identifies a dual-domain mechanism in the Flower protein that coordinates extracellular vesicle-mediated fitness selection and cell-intrinsic survival in astrocytes, with implications for Alzheimer's disease.

The paper shows that IFNγ expression in CD8+ T cells correlates with increased cytotoxicity and identifies CRTAM as a regulator of IFNγ induction.

The paper introduces IVEA, a deep-learning platform for automated exocytosis analysis in live-cell imaging, which is faster and more reliable than manual methods.

This study shows that gut miRNA depletion in App-knock-in mice alters microbiome composition, reduces Aβ load, and induces anxiety, suggesting miRNA manipulation could influence AD pathogenesis.

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

The paper identifies lytic IFNγ stored in granzyme B-containing cytotoxic granules and co-secreted with GzmB by effector CD8⁺ T cells during immunological synapse formation.

The paper identifies a GABA/TNF-related cytokine-mediated communication pathway between interneurons and oligodendrocyte precursor cells that affects myelination and cognitive behavior.