Ute Becherer

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

The paper describes stenocytosis, a mechanism by which CTLs transfer supramolecular attack particles into target cells through narrow actin gaps.

The paper introduces IVEA, a deep-learning platform for automated exocytosis analysis in live-cell imaging, which is faster and more reliable than manual methods.

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

The paper identifies lytic IFNγ stored in granzyme B-containing cytotoxic granules and co-secreted with GzmB by effector CD8⁺ T cells during immunological synapse formation.