Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies
Felipe Martelli, Natalia H Hernandes, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusita Rupasinghe, Charles Robin, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo Jozef Bellen
This study shows that low doses of spinosad cause lysosomal defects, oxidative stress, lipid dysregulation, and neurodegeneration in Drosophila.
eLife · Jan 31, 2022Peer-reviewedNeuroscience