Kartik Venkatachalam

In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

Neuronal glycolytic reprogramming drives lethality via accelerated aging in a Drosophila model of tauopathy

This study shows that tau-induced glycolytic reprogramming in Drosophila neurons accelerates aging and causes lethality, indicating glycolysis drives rather than protects against tauopathy.

Intracellular Lactate Dynamics Reveal the Metabolic Diversity of Drosophila Glutamatergic Neurons

The paper investigates lactate dynamics in Drosophila glutamatergic neurons under nutrient deprivation, finding that lactate consumption correlates with mitochondrial density and temporal correlations exist between pre- and post-barrier disruption lactate levels.

Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila model of ALS

This paper identifies bioenergetic dysfunction due to reduced activity-induced mitochondrial ATP production as the cause of synaptic defects in a Drosophila ALS model.

Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies

This study shows that low doses of spinosad cause lysosomal defects, oxidative stress, lipid dysregulation, and neurodegeneration in Drosophila.